Research

Our laboratory seeks to utilize and synthesize micro and nanoscale materials, develop novel micro and nanodevices, and micro and nanosystems to advance the research in life science, biomedical engineering, plant science, and renewable energy harvesting and storage.

Our research has been generously supported by NSF, National Academy of Sciences (NAS), NASA/LaSPACE, AFRL, DOD, DOE, US EDA/EPA, Board Regents of Louisiana, Methodist Hospital Research Institute, and Industries.

Cell-, Tissue- and Organ-on-Chip

References

1. F. Rubby, C. Fonder, S. Uchayash, X. Liang, D. Sakaguchi and L. Que, "Assessment of the behaviors of an in vitro brain model on chip under shockwave impacts," ACS Applied Materials and Interfaces, 16, 26, 33246–33258 (2024)

2. S. Mao, C. Fonder, F. Rubby, G. Phillips, D. Sakaguchi, and L. Que, "An integrated microfluidic chip for studying the effects of neurotransmitters on neurospheroids," Lab on a Chip, 23, 1649-1663 (2023), 2023

3. R. Yang, C. Fonder, D. Jiles, D. Sakaguchi, and L. Que, "A microfluidic chip for growth and characterization of adult rat hippocampal progenitor cell neurospheroids," IEEE Journal of Microelectromechanical Systems, 31, 37 (2022)

4. R. Yang, J. Boldrey, D. Jiles, I. Schneider, and L. Que, "On chip detection of glial cell-derived neurotrophic factor secreted from dopaminergic cells under magnetic stimulation," Biosensors and Bioelectronics, 182, 113179 (2021)

5. X. Che, J. Boldrey, X. Zhong, S. Unnikandam-Veettil, I. Schneider, D. Jiles, and L. Que, "On-chip studies of magnetic stimulation effect on single neural cell viability and proliferation on glass and nanoporous surfaces," ACS Applied Materials and Interfaces, 10(34), 28269-28278 (2018)

6. J. Nuhn, S. Gong, X. Che, L. Que, and I. Schneider, "Microtissue Size and Cell-cell Communication Modulate Cell Migration in Arrayed 3D Collagen Gels," Biomedical Microdevices, 20(3), 62 (2018)

Updated: July 26, 2024

Flexible and wearable devices and systems

References

1. X. Ding, M. Chen, X. Liang, and L. Que, "Soft contact lens with embedded moire patterns-based intraocular pressure sensors," IEEE Journal of Microelectromechanical Systems, 31(6) pp. 971-976, 2022

2. X. Ding, G. Ben-Shlomo, and L. Que, "Soft contact lens with embedded microtubes for sustained and self-adaptive drug delivery for glaucoma treatment," ACS Applied Materials & Interfaces, 12 (41), 45789-45795 (2020)

3. C. Song, G. Ben-Shlomo, and L. Que, "A multifunctional smart soft contact lens device enabled by nanopore thin film for glaucoma diagnostics and in situ drug delivery," IEEE Journal of Microelectromechanical Systems, v. 28, no.5, 810 (2019)

4. C. Song, X. Ding, and L. Que, "High-resolution, flexible and transparent nanopore thin film sensor enabled by cascaded Fabry-Perot effect," Optics Letters, v. 43, no.13, 3057-3060 (2018)

5. C. Song, P. Deng, X. Ding, L. Que, "A flexible nanopore thin film enabled device for pressure sensing and drug release," IEEE Transactions on Nanotechnology, 17(5), (962-967) 2018

Updated: July 26, 2024

Nanostructure-enabled Biosensing & Imaging Platform

References

1. S. Mao, J. Zhang, X. Ding, V. A. Vuong, J. Song and L. Que, "An integrated sensing chip for ultrasensitive label-free detection of the products of loop-mediated isothermal amplification," ACS Sensors, 8(6), 2255-2562 (2023)

2. C. Chen*, S. Feng*, M. Zhou, L. Que, W. Wang, "Development of a structure-switching aptamer-based nanosensor for salicylic acid detection," Biosensors and Bioelectronics, 140, 111342 (2019)

3. C. Song, P. Deng, and L. Que, "Rapid multiplexed detection of Beta-amyloid and Total-tau as biomarkers for Alzheimer's disease in cerebrospinal fluid," Nanomedicine: Nanotechnology, Biology and Medicine, v.14, no.6, 1845-1852 (2018)

4. S. Alzghoul, M. Hailat, S. Zivanovic, L. Que, G. Shah, "Measurement of serum prostate cancer biomarkers using a nanopore thin film based optofluidic chip," Biosensors and Bioelectronics, 77, 491-498 (2016)

5. X. Che, Y. He, H. Yin, and L. Que, "A molecular beacon biosensor based on the nanostructured aluminium oxide surface," Biosensors and Bioelectronics, 72, 255-260 (2015)

Updated: July 26, 2024

Microfluidic Chips for Single Cell Analysis, Sensing & Controlled Drug Release

References

1. S. Mao, A. Sarkar, Y. Wang, C. Song, D. LeVine, X. Wang, and L. Que, "Microfluidic chip grafted with integrin tension sensors for evaluating the effects of flowing shear stress and ROCK inhibitor on platelets," Lab on a Chip, 21, 3128-3136 (2021)

2. S. Feng, C. Chen, C. Song, X. Ding, W. Wang and L. Que, "Optical aptamer-based sensors for detecting plant hormones," IEEE Sensors Journal, 21(5), 5743-5750 (2021)

3. X. Li, H. Yin and L. Que, "A nanostructured aluminum oxide-based microfluidic device for enhancing immunoassay's fluorescence and detection sensitivity," Biomedical Microdevices, 16(5), 771-777 (2014)

4. W. Cheng, Y. He, A. Chang and L. Que, "A microfluidic chip for controlled release of drugs from microcapsules," Biomicrofluidics, 7, 064102 (2013)

Updated: July 26, 2024

Nanostructures, Micro/Nano Energy Harvesting, IR Sensing and Imaging, Nanomaterial Characterization

References

1. Md F. Rubby, C. Fonder, S. Uchayash, S. A. Siddiqui, I. Schneider, D. S. Sakaguchi, and L. Que, "In situ monitoring of neurotransmitters using a polymer nanostructured electrochemical sensing microchip," Microchemical Journal, 111159 (2024)

2. X. Ding, F. Rubby, S. Que, S. Uchayash, and L. Que, "A facile process for fabrication of silicon micro-nanostructures of different shapes as the molds for fabricating flexible micro-nanostructures and wearable sensors," ACS Applied Materials and Interfaces, 15, 9, 12202-12208 (2023)

3. Y. He, X. Che and L. Que, "A top-down fabrication process for vertical hollow silicon nanotubes," IEEE Journal of Microelectromechanical Systems, 25(4), 662-667 (2016)

4. Y. He, S. Vasiraju and L. Que, "Hybrid nanomaterial-based nanofluids for micropower generation," RSC Advances, 4(5), 2433-2439 (2014)

5. Y. Tseng, Y. He and L. Que, "Ultrasensitive thin film infrared sensors enabled by hybrid nanomaterial," Analyst, 138, 3053-3057(2013)

6. Y. Tseng, Y. He, S. Lakshmanan, C. Yang, W. Chen and L. Que, "Optical and thermal response of single-walled carbon nanotubes-copper sulfide nanoparticles hybrid nanomaterials," Nanotechnology, 23 (2012) 455708

7. Z. Gong, Y. He, A. Tseng, C. O'Neal and L. Que, "A micromachined carbon nanotube film cantilever-based energy cell," Nanotechnology, 23 (2012) 335401

Updated: July 26, 2024