Research

Our laboratory seeks to utilize and synthesize micro and nanoscale materials, develop novel micro and nanodevices, and micro and nanosystems to advance the research in life science, biomedical engineering, plant science, and renewable energy harvesting and storage.

Our research has been generously supported by NSF, National Academy of Sciences (NAS), NASA/LaSPACE, AFRL, DOD, DOE, US EDA/EPA, Board Regents of Louisiana, Methodist Hospital Research Institute, and Industries.

Cell-, Tissue- and Organ-on-Chip

References

1. X. Che, J. Boldrey, X. Zhong, S. Unnikandam-Veettil, I. Schneider, D. Jiles, and L. Que, "On-chip studies of magnetic stimulation effect on single neural cell viability and proliferation on glass and nanoporous surfaces," ACS Applied Materials and Interfaces, 10(34), 28269-28278 (2018)

2. J. Nuhn, S. Gong, X. Che, L. Que, and I. Schneider, "Microtissue Size and Cell-cell Communication Modulate Cell Migration in Arrayed 3D Collagen Gels," Biomedical Microdevices, 20(3), 62 (2018)

3. X. Che, J. Nuhn, I. Schneider, L. Que, "High Throughput Studies of Cell Migration in 3D Microtissues Fabricated by a Droplet Microfluidic Chip," Micromachines, 7(5), 84(2016). (Invited paper)

Updated: September 26, 2018

Nanostructure-enabled Biosensing & Imaging Platform

References

1. C. Song, P. Deng, and L. Que, "Rapid multiplexed detection of Beta-amyloid and Total-tau as biomarkers for Alzheimer's disease in cerebrospinal fluid," Nanomedicine: Nanotechnology, Biology and Medicine, v.14, no.6, 1845-1852 (2018)

2. S. Alzghoul, M. Hailat, S. Zivanovic, L. Que, G. Shah, "Measurement of serum prostate cancer biomarkers using a nanopore thin film based optofluidic chip," Biosensors and Bioelectronics, 77, 491-498 (2016)

3. X. Che, Y. He, H. Yin, and L. Que, "A molecular beacon biosensor based on the nanostructured aluminium oxide surface," Biosensors and Bioelectronics, 72, 255-260 (2015)

Updated: September 26,2018

High Throughput Controlled Drug Release & Single Cell Analysis

References

1. C. Song, P. Deng, X. Ding, L. Que, "A flexible nanopore thin film enabled device for pressure sensing and drug release," IEEE Transactions on Nanotechnology, 17(5), (962-967) 2018

2. C. Song, X. Che, L. Que, "A nanopore thin film enabled optical platform for drug loading and release," Optics Express, 25 (16), 19391-19397 (2017)

3. W. Cheng, Y. He, A. Chang and L. Que, "A microfluidic chip for controlled release of drugs from microcapsules," Biomicrofluidics 7, 064102 (2013)

Updated: September 26, 2018

Micro/Nano Energy Harvesting, IR Sensing and Imaging, Nanomaterial Characterization

References

1. Y. Tseng, Y. He and L. Que, "Ultrasensitive thin film infrared sensors enabled by hybrid nanomaterial," Analyst, 138, 3053-3057(2013)

2. Y. Tseng, Y. He, S. Lakshmanan, C. Yang, W. Chen and L. Que, "Optical and thermal response of single-walled carbon nanotubes-copper sulfide nanoparticles hybrid nanomaterials," Nanotechnology, 23 (2012) 455708

3. Z. Gong, Y. He, A. Tseng, C. O'Neal and L. Que, "A micromachined carbon nanotube film cantilever-based energy cell," Nanotechnology, 23 (2012) 335401

Updated: September 26, 2018