Publications and Patents

Book:
1. Handbook of Single Molecule Analysis, with P. Kundu, R. Pradhan and F. Tseng (Editors), Springer Nature (in progress), 2019-

Book Chapters:
1. L. Que, Nanostructured Aluminum Oxide-based Optical Biosensing and Imaging, in Optical MEMS for Chemical Analysis and Biomedicine, H. Jiang (Editors), pp. 391-433. London: IET, 2016
2. L. Que, Thermal Actuation, in Comprehensive Microsystems, Y. Gianchandani, O. Tabata, H. Zappe (Editors in Chief), Volume 2, pp. 69-100. Amsterdam: Elsevier, 2008
3. L. Que and Y. B. Gianchandani, MOEMS Actuation and Sensing, in Micro-Opto-Electro-Mechanical Systems, M. E. Motamedi (Editor), pp. 121-210. SPIE–Optical Engineering PRESS, 2005

Recent (from 2009 --- ) Peer Reviewed Publications (J: Journal, C: Conference):
[J81] C. Song, G. Ben-Shlomo, and L. Que, "A multifunctional smart soft contact lens device enabled by nanopore thin film for glaucoma diagnostics and in situ drug delivery," Journal of Microelectromechanical Systems 2019 (under revision)
[C80] S. Mao, S. Feng, and L. Que, "Detection of autoantibodies for Type 1 diabetes using label-free optical sensors," Proc. Transducers'2019 , pp. 578-581, 2019
[C79] X. Ding, C. Song, and L. Que, "Fabrication of contact lens device with integrated microtubes for in situ extended drug delivery for ocular disease treatment," Proc. Transducers'2019, pp. 306-309, 2019
[C78] R. Yang, E. Kozik, D. Jiles, D. Sakaguchi, and L. Que, "Studies of neurospheres cultured using adult hippocampal progenitor cells under off-chip magnetic stimulation," Proc. Transducers'2019 , pp. 756-759, 2019
[J77] C. Chen*, S. Feng*, M. Zhou, L. Que, W. Wang, "Development of a structure-switching aptamer-based nanosensor for salicylic acid detection," Biosensors and Bioelectronics, *first author, 140, 111342 (2019)
[J76] Y. He, C. Song, and L. Que, "Nanoforest-based SERS sensor fabricated using a maskless process for detecting chemical and pathogen," Microsystem Technologies (in press), 2019
[J75] R. Yang, Z. Gong, X. Zhang, and L. Que, "Single-walled carbon nanotubes (SWCNTs) and poly(3,4-ethylenedioxythiophene) nanocomposite microwire-based electronic biosensor fabricated by microlithography and layer-by-layer nanoassembly," Journal of Nanoscience and Nanotechnology, 19, 7591-7595 (2019)
[J74] X. Che, J. Boldrey, X. Zhong, S. Unnikandam-Veettil, I. Schneider, D. Jiles, and L. Que, "On-chip studies of magnetic stimulation effect on single neural cell viability and proliferation on glass and nanoporous surfaces," ACS Applied Materials and Interfaces, 10(34), 28269-28278 (2018)
[J73] C. Song, P. Deng, and L. Que, "Rapid multiplexed detection of Beta-amyloid and Total-tau as biomarkers for Alzheimer's disease in cerebrospinal fluid," Nanomedicine: Nanotechnology, Biology and Medicine, v.14, no.6, 1845-1852 (2018)
[J72] C. Song, X. Ding, and L. Que, "High-resolution, flexible and transparent nanopore thin film sensor enabled by cascaded Fabry-Perot effect," Optics Letters, v. 43, no.13, 3057-3060 (2018)
[J71] X. Che, P. Deng, J. Song, and L. Que, "Studies of mechanisms and characteristics of anodic aluminum oxide thin film-enabled fluorescence enhancement," Applied Nanoscience, 8(6), 1445-1452 (2018)
[J70] J. Nuhn, S. Gong, X. Che, L. Que, and I. Schneider, "Microtissue Size and Cell-cell Communication Modulate Cell Migration in Arrayed 3D Collagen Gels," Biomedical Microdevices, 20(3), 62 (2018)
[J69] C. Song, P. Deng, X. Ding, L. Que, "A flexible nanopore thin film enabled device for pressure sensing and drug release," IEEE Transactions on Nanotechnology, 17(5), (962-967) 2018
[J68] S. Feng, C. Chen, W. Wang, L. Que, "An aptamer nanopore-enabled microsensor for detection of theophylline," Biosensors and Bioelectronics,105, 36-41 (2018)
[J67] C. Song, X. Che, L. Que, "A nanopore thin film enabled optical platform for drug loading and release," Optics Express, 25 (16), 19391-19397 (2017)
[C66] S. Gong, C. Song, D. Qiao, and L. Que, "Detection of Chemical Nutrients in Water Using a Fluidic Microplasma Chip with Enhanced Optical Collection Efficiency," Proc. MicroTAS 2017
[C65] X. Che, J. Nuhn, I. Schneider, and L. Que, "A Nanostructure-enabled Fluorescence Chip for Monitoring Cell Secretion," Proc. IEEE NANO conference, pp.1039-1042, 2017 (Highlighted as a 30-minute talk at the conference)
[C64] P. Deng, C. Song, and L. Que, "Label-free Monitoring of Alzheimer's Disease Biomarkers in Cerebrospinal Fluid," Proc. IEEE NANO conference, pp. 1074-1077, 2017 (Highlighted as a 30-minute talk at the conference)
[C63] C. Song, P. Deng, and L. Que, "A Flexible Transparent Nanopore Device for Pressure Sensing and Drug Release," Proc. IEEE NANO conference, pp. 1047-1050, 2017
[C62] X. Che, J. Boldrey, X. Zhong, I. Schneider, D. Jiles, and L. Que, "Studies of Single Neuron Cell Growth on Nanoporous Surface and under Transcranial Magnetic Stimulation," Proc. IEEE NANO conference, pp.1056-1059, 2017
[C61] C. Song, C. Chen, X. Che, W. Wang, and L. Que, "Detection of plant hormone abscisic acid (ABA) using an optical aptamer-based sensor with a microfluidic capillary interface," Proc. IEEE MEMS conference, pp. 370-373, 2017
[C60] S. Feng, C. Chen, X. Che, W. Wang, and L. Que, "Rapid detection of theophylline using aptamer-based nanopore thin film sensor," Proc. IEEE Sensors Conference. pp. 1658-1660, 2016
[C59] X. Che, J. Nuhn, S. Gong, I. Schneider, and L. Que, "Studies of cell behaviors in 3D microtissues in a microfluidic device: growth and migration," Proc. IEEE Sensors Conference, pp. 1183-1185, 2016
[C58] C. Song, X. Che, and L. Que, "Controlled drug loading and release enabled by nanopore thin film and layer-by-layer nanoassembly," Proc. IEEE Sensors Conference, pp. 199-201, 2016
[C57] X. Che, P. Deng, and L. Que, "Nanostructured aluminum oxide thin film-based fluorescent sensing: Effects of nanopore size, density and thickness," Proc. IEEE Sensors Conference, pp. 862-864, 2016
[C56] Y. He, C. Song, C. Wang, C. Yu and L. Que, "A nanoforest-based SERS sensor fabricated by Bosch process for multiplexed chemical detection," Proc. IEEE Sensors Conference, pp. 523-525, 2016
[J55] Y. He, X. Che and L. Que, "A top-down fabrication process for vertical hollow silicon nanotubes,"Journal of Microelectromechanical Systems, 25(4), 662-667 (2016)
[J54] X. Che, J. Nuhn, I. Schneider, L. Que, "High Throughput Studies of Cell Migration in 3D Microtissues Fabricated by a Droplet Microfluidic Chip," Micromachines, 7(5), 84(2016). (Invited paper)
[J53] S. Alzghoul, M. Hailat, S. Zivanovic, L. Que*, G. Shah*, "Measurement of serum prostate cancer biomarkers using a nanopore thin film based optofluidic chip," Biosensors and Bioelectronics, 77, 491-498 (2016)
[C52] S. Alzghoul, M. Hailat, S. Zivanovic, L. Que*, G. Shah*, "Development of nanopore thin film-based optofluidic sensors for measurement of circulating prostate cancer markers," presented at Gordon Research Conference: Cancer Nanotechnology, 2015
[J51] X. Che, Y. He, H. Yin, and L. Que, "A molecular beacon biosensor based on the nanostructured aluminium oxide surface," Biosensors and Bioelectronics, 72, 255-260 (2015)
[C50] S. Alzghoul, M. Hailat, S. Zivanovic, G. Shah*, and L. Que*, "Detection of neuroendocrine marker in blood samples using an optofluidic chip," Proceeding of Transducers, pp.1703-1706, 2015
[C49] Y. He, X. Che, and L. Que, "Fabrication of vertically aligned silicon nanotubes using nanosphere beads as the mask and Bosch process," Proceeding of Transducers, pp.1401-1404, 2015
[J48] P. Pathak and L. Que, "Characterization of FET biosensors fabricated using layer-by-layer nanoassembly process," Journal of Nanoscience and Nanotechnology, 15, 9689-9692 (2015)
[J47] X. Li and L. Que, "Fluorescence enhancement enabled by nanomaterials and nanostructured substrates: A brief review," Reviews in Nanoscience and Nanotechnology, 3(3), 161-176 (2014)
[J46] Y. He, X. Che and L. Que, "Characterization of the silicon nanopillar-surface filled and grafted with nanomaterials," Materials Research Express, 1(3), 035045 (2014)
[J45] H. Yin, X. Li and L. Que, "Fabrication and characterization of the arrayed aluminum oxide thin film micropatterns on glass substrate," Microelectronic Engineering, 128, 66-70 (2014)
[J44] X. Li, H. Yin and L. Que, "Nanostructured aluminum oxide-based fluorescence immunosensor," Biomedical Microdevices, 16(5), 771-777 (2014)
[J43] Y. He, S. Vasiraju and L. Que, "Hybrid nanomaterial-based nanofluids for micropower generation," RSC Adv., 4(5), 2433-2439 (2014)
[J42] Y. He, X. Li and L. Que, "A Transparent Nanostructured Optical Biosensor," Journal of Biomedical Nanotechnology 10 (5), 767-774 (2014)
[J41] W. Cheng, Y. He, A. Chang and L. Que, "A microfluidic chip for controlled release of drugs from microcapsules," Biomicrofluidics 7, 064102 (2013)
[C40] X. Li, H. Yin and L. Que, "A microfluidic nanostructured fluorescence sensor for biomolecular binding detection," Proc. IEEE Sensors Conference, pp.625-628, 2013
[C39] Y. He, S. Vasiraju and L. Que, "A fluidic microenergy generator enabled by hybrid nanomaterial nanofluids," Proc. IEEE Sensors Conference, pp.1420-1423, 2013
[C38] X. Li, H. Yin, T. Wang and L. Que, "Optical characterization of micropatterned anodic aluminum oxide (AAO) using UV light for its fluorescence applications," Proc. IEEE Sensors Conference, pp.1208-1211, 2013
[C37] W. Cheng, Y. He and L. Que, "Controlled drug release in a microfluidic device with droplet merging and storage functions," Proc. IEEE Sensors Conference, pp.1815-1818, 2013
[J36] Y. Tseng, Y. He and L. Que, "Ultrasensitive thin film infrared sensors enabled by hybrid nanomaterial," Analyst, 138, 3053-3057(2013)
[J35] X. Li, Y. He and L. Que, "Fluorescence detection and imaging of biomolecules using the micropatterned nanostructured aluminum oxide," Langmuir, 2013, 29 (7), pp 2439-2445
[C34] Y. Tseng, Y. He, S. Vasiraju, Z. Gong, W. Cheng, W. Chen and L. Que, "Using nanomaterials for local temperature enhancement for thermoelectric microgenerators," Proceeding of Power MEMS, pp. 235-238, 2012
[C33] P. Dahal, P. Pathak, S. Yadav, Z. Gong and L. Que, "Liquid energy harvesting device using carbon nanotube thin film," Proceeding of Power MEMS, pp. 303-306, 2012
[J32] Y. Tseng, Y. He, S. Lakshmanan, C. Yang, W. Chen and L. Que, "Optical and thermal response of single-walled carbon nanotubes-copper sulfide nanoparticles hybrid nanomaterials," Nanotechnology, 23 (2012) 455708 (online on October 22, 2012)
[J31] X. Li, Y. He, T. Zhang and L. Que, "Aluminum oxide nanostructure-based substrates for fluorescence enhancement," Optics Express, Vol. 20, No. 19, pp. 21272-21277 (2012)
[C30] Y. He, W. Cheng, Y. Zhao, Y. Lvov and L. Que, "Controlled release of drugs with nanostructured capsules in microdroplets," Proc. of IEEE SENSORS, pp.781-784, 2012
[J29] T. Zhang, Y. He, J. Wei and L. Que, "Nanostructured optical microchips for cancer biomarker detection," Biosensors and Bioelectronics, 38 (2012), pp. 382-388 (online on June 26, 2012)
[J28] Z. Gong, Y. He, A. Tseng, C. O'Neal and L. Que, "A micromachined carbon nanotube film cantilever-based energy cell," Nanotechnology, 23 (2012) 335401 (online on July 31, 2012)
[J27] Y. He, X. Li and L. Que, "Fabrication and characterization of lithographically patterned and optically transparent anodic aluminum oxide (AAO) nanostructure thin film," Journal of Nanoscience and Nanotechnology (JNN), Vol. 12, No. 10, 7915-7921 (2012)
[C26] X. Li, Y. He, T. Zhang, T. Lee and L. Que, "Lithographically patterned anodic aluminum oxide (AAO) nanostructures for fluorescence enhancement," Proceeding of IEEE NANO 2012, pp. 1-4, 2012
[C25] Z. Gong, A. Tseng, Y. He, C. O'Neal and L. Que, "Energy scavenging microdevices enabled by carbon nanotube film," Proceeding of IEEE NANO 2012
[J24] Z. Gong, A. Tseng, Y. He, and L. Que, "Studies of self-reciprocating characteristic of carbon nanotube film-based cantilevers under light and thermal radiation," Journal of Nanoscience and Nanotechnology (JNN), Vol. 12, No. 1, 350-355 (2012)
[J23] T. Zhang, P. Pathak, S. Karandikar, R. Giorno, and L. Que, "A polymer nanostructured Fabry-Perot interferometer based biosensor," Biosensors and Bioelectronics, 30, 128 (2011) (published online on 09/06/2011)
[J22] P. Pathak, H. Zhao, Z. Gong, T. Zhang, F. Nie, K. Cui, Z. Wang, S. Wong and L. Que, "Real-time monitoring of cell viability using direct electrical measurement with a patch-clamp microchip," Biomedical Microdevices, V. 13, No. 5, 949 (2011) (published online on 06/23/2011)
[C21] Z. Gong, V. Kotipalli, Y. He, J. Soman, C. O'Neal and L. Que, “Fabrication of carbon nanotube film-piezoelectric (CNF-PZT) microcantilevers for energy harvesting application,” 2-page abstract in Proceeding of EIPBN 2011 (oral presentation)
[C20] Y. He, X. Zhang, P. Dahal, A. Koirala, Z. Gong, A. Gunasekaran, Y. Lvov and L. Que, “Nanocomposite-beam based microresonator fabricated by combining microlithography and layer-by-layer nanoassembly,” 2-page abstract in Proceeding of EIPBN 2011 (poster presentation)
[J19] S. Penmetsa, K. Nagrajan, Z. Gong, D. Mills, and L. Que, “Biological Cell Controllable Patch-Clamp Microchip,” Appl. Phys. Lett. 97, 263702 (2010) (also selected for the January 1, 2011 issue of Virtual Journal of Biological Physics Research)
[J18] Z. Gong, H. Zhao, T. Zhang, F. Nie, P. Pathak, K. Cui, Z. Wang, S. Wong and L. Que, “Drug Effects Analysis on Cells Using a High Throughput Microfluidic Chip,” Biomedical Microdevices, V. 13, No. 1, 215 (2011) (published online on 10/27/2010)
[J17] V. Kotipalli, Z. Gong, P. Pathak, T. Zhang, Y. He, S. Yadav and L. Que, “Light and Thermal Energy Cell Based on Carbon Nanotube Films,” Appl. Phys. Lett. 97, 124102 (2010) (also selected for the September 27, 2010 issue of Virtual Journal of Nanoscale Science & Technology)
[J16] T. Zhang, Z. Gong, R. Giorno, L. Que, “A Nanostructured Fabry-Perot Interferometer,” Optics Express,Vol. 18, No. 19, pp.20282-20288 (2010) (highlighted as a newsbreak "Polymer uFPI beats semiconductor-based design for biosensing" in Laser Focus World Magazine in November 2010)
[J15] T.  Zhang, S. Talla, Z. Gong, S. Karandikar, R. Giorno, L. Que, “Biochemical Sensing with A Polymer-Based Micromachined Fabry-Perot Sensor,” Optics Express, Vol. 18, No. 17, pp.18394-18400 (2010)
[C14] P. Pathak, H. Zhao, Z. Gong, F. Nie, T. Zhang, S. Wong, L. Que, “Real-Time Tagless Monitoring of Cell Viability Using Patch-Clamp Microdevices,” Proc. of IEEE Sensors, pp.2482-2485, 2010
[C13]  V. Kotipalli, Z. Gong, Y. He, S. Yadav, S. Penmetsa, J. Wei, L. Que, “Carbon Nanotube Film-Based Cantilever for Light and Thermal Energy Harvesting,” Proc. of IEEE Sensors, pp.1165-1168, 2010
[C12] T. Zhang, S. Karandikar, Z. Gong, R. Giorno, L. Que, “Label-Free Biosensing Using A Nanostructured Fabry-Perot Interferometer,” Proc. of IEEE Sensors, pp.2065-2068, 2010
[C11] Z. Gong, S. Karandikar, X. Zhang, V. Kotipalli, Y. Lvov, L. Que, “Composite Nanomaterial Thin Film-Based Biosensors,” Proc. of IEEE Sensors, pp.29-32, 2010
[C10] Z. Gong, F. Nie, T. Zhang, P. Pathak, Z. Wang, H. Zhao, S. Wong, L. Que, “High Throughput Analysis of Drug Effects on Single Breast Cancer Cells Using Droplet-Microfluidic Devices,” Proc. of IEEE Intl. Conf. on MEMS, pp. 1015-1018, 2010
[C9] T. Zhang, Z. Gong, R. Giorno, L. Que, "Signal Sensitivity and Intensity Enhancement for A Polymer-Based Fabry-Perot Interferometer with Embedded Nanostructures in Its Cavity", Proc. of 15th International Conference on Solid-State Sensors, Actuators & Microsystems (Transducers'09), pp. 2310-2313, 2009
[C8] S. Penmetsa, K. Nagrajan, Z. Gong, D. Mills, L. Que, "A Patch-Clamp Device with Cell sorting and Positioning Function", Proc. of 15th International Conference on Solid-State Sensors, Actuators & Microsystems (Transducers'09), pp. 81-84, 2009
[C7] Z. Gong, S. Penmesta, Z. Zheng, Y. Lvov, L. Que, "Encapsulation of Microparticles and Biomolecules Based on Layer-by-Layer Nanoassembly Techniques with Microfluidics Droplet Devices", Proc. of 15th International Conference on Solid-State Sensors, Actuators & Microsystems (Transducers' 09), pp. 1043-1046, 2009
[C6] T. Zhang, Z. Gong, L. Que, "A White-Light Source Operated Polymer-Based Micromachined Fabry-Perot Chemo/Biosensor",Proc. of IEEE Intl. Conf. on NEMS, pp. 177-180, 2009
[C5] Z. Gong, K. Nagrajan, S.Penmetsa, D. Mills, L. Que, "A Patch-Clamp Device with Integrated Actuators for Cell Selection and Positioning", Proc. of IEEE Intl. Conf. on NEMS, pp. 278-281, 2009
[C4] S. Madisetti, Z. Zheng, Z. Gong, S. Penmetsa, Y. Lvov, L. Que, "Layer-by-Layer Nanoscale-Coating of Microparticles with A Droplet Microfluidic Device", Proc. of IEEE Intl. Conf. on NEMS, pp. 440-443, 2009
[C3] S. Penmetsa, T. Zhang, Z. Gong, T. Lee, L. Que, "Design and Modeling of A Tunable Optical Antenna Enabled by A Micromachined Actuator", Proc. of IEEE Intl. Conf. on NEMS, pp. 172-176, 2009
[J2] B. Mitra, C. Wilson, L. Que, P. Selvaganapathy, and Y. B. Gianchandani, "Microfluidic Discharge-Based Optical Sources for Detection of Biochemical," Lab-on-a-Chip, pp.60-65, 2006
[J1] K. Udeshi, K. Liao, L. Que, Y. Gianchandani, and A. Galvanauskas, “Programmable Optical Wave Form Shaper on A Microchip," Applied Physics Letters, 89, 031120, 2006 (also selected for the August 7, 2006 issue of Virtual Journal of Nanoscale Science & Technology)

 

Selected Patents:
21. Optically and thermally responsive nanohybrid materials, US patent# 9,728,703
20. Microchip for point-of-care diagnostics, US patent application (March 2013) & pending
19. Piezoelectric photovoltaic micropower generator and method, US Patent# 8,901,802
18. Automated patch-clamp microdevices, US Patent applications (October 2010)
17. Raman System on a chip, US Patent# 7,505,128
16. Microfluidic device and methods for droplet generation and manipulation, US Patent App. 12/208,445, 2008
15. Dynamic plasmonics-enabled single enhancement, a device comprising the same, and a method using the same. US Patent# 7,612,883
14. System and method for optical power management. US Patent# 7,692,785
13. Method and apparatus for improved signal to noise ratio in Raman signal detection for MEMS based spectrometers. US Patent# 7,586,603
12. Method and apparatus for improved signal to noise ratio in Raman signal detection for MEMS based spectrometers. US Patent# 7,586,602
11. Micro-electromechanical system Fabry-Perot filter mirrors. US Patent# 7,573,578
10. Actuator for micro-electromechanical system Fabry-Perot filter. US Patent# 7,551,287
9. Optical waveform shaping. US Patent App. 11/652,947. US 20070196048 A1
8. Collection probe for use in a Raman spectrometer system and methods of making and using the same. US Patent# 7,411,670
7. A battery-operated, wavelength-tunable, optical source for fluorescent detection of biochemicals. US Patent# 7,142,303
6. Micromechanical phase-shifting gate optical modulator. US Patent# 6,337,718
5. Latching mechanism for MEMS actuator and method of fabrication. US Patent# 6,549,107
4. Two-dimensional tunable filter array for a matrix of integrated fiber optic input-output light channels. US Patent# 6,449,410
3. Irregularly shaped actuator fingers for a micro-electromechanical system Fabry-Perot filter. US Patent# 7,796,269
2. Gating voltage control system and method for electrostatically actuating a micro-electromechanical device. US Patent# 7,473,859
1. Collection probe for use in a Raman spectrometer system and methods of making and using the same. US Patent# 7,411,670